Acetylcholinesterase

Acetylcholinesterase Involvement in Apoptosis

To date, more than 40 different types of cells from primary cultures or cell lines have shown AChE expression during apoptosis and after the induction apoptosis by different stimuli. It has been well-established that increased AChE expression or activity is detected in apoptotic cells after apoptotic stimuli in vitro and in vivo, and AChE could be therefore used as a marker of apoptosis. AChE i...

Molecular dynamics of acetylcholinesterase.

Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site. The most recent work points to the complex and spatially extensive nature of such motions and suggests possible modes ...

Inhibitors of Acetylcholinesterase

Turnover time of acetylcholinesterase.

The turnover time of the enzyme, acetylcholinesterase, is of biological interest because of the role proposed for its substrate in nerve conduction. According to the theory of Nachmansohn, the action of acetylcholine on a receptor protein is responsible for the generation of bioelectric potentials by increasing sodium conductance. Acetylcholinesterase, which inactivates acetylcholine by hydroly...

Acetylcholinesterase inhibitors attenuate angiogenesis

Donepezil {(RS)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one} is a reversible acetylcholinesterase inhibitor and used for treatment of patients with AD (Alzheimer's disease). Recent studies showed that treatment with donepezil reduced production of inflammatory cytokines in PBMCs (peripheral blood mononuclear cells). It was also reported that muscle-derived inflammatory...